Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4_94 genotype and RA in people of European descent (OR 1
Meta-analysis of previously published studies and our data confirmed no significant association between the PADI4_94 genotype and RA in people of European descent (OR 1.06, 95% CI 0.99 to 1 1.13, p=0.12). Conclusion In the largest study performed to date, the genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations. Introduction Rheumatoid arthritis (RA) is a complex autoimmune disease in which genetic and environmental factors contribute to the pathogenesis. in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1 1.01 (95% CI 0.96 to 1 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with either shared epitope or was detected.…