(A) Level of IgM surface expression
(A) Level of IgM surface expression. ITAM of K1 was required for its signal-transducing activity. Furthermore, tyrosine residues of the putative ITAM of K1 were phosphorylated upon activation, and this allowed subsequent binding of SH2-comprising proteins. These results demonstrate the KSHV transforming protein K1 contains a functional ITAM in its cytoplasmic website and that it can transduce signals to induce cellular activation. Engagement of the B-cell antigen receptor (BCR) and the T-cell antigen receptor (TCR) initiates multiple intracellular signals that can lead to cellular proliferation and the acquisition of complex effector functions. Analysis of sequence elements responsible for the signaling properties of the transducing subunits Temsirolimus (Torisel) of BCR and TCR offers led to the identification of the immunoreceptor tyrosine-based activation motif (ITAM) (3, 8, 36, 37). This motif consists…